New strategy of antiangiogenic therapy for hepatocellular carcinoma.

@article{Wu2008NewSO,
  title={New strategy of antiangiogenic therapy for hepatocellular carcinoma.},
  author={Xiong-Zhi Wu},
  journal={Neoplasma},
  year={2008},
  volume={55 6},
  pages={472-81}
}
Hepatocellular carcinoma (HCC) is a hypervascular tumor, and tumor progression and prognosis is associated with angiogenesis. Extracellular matrix remodeling and inflammation play important roles in hepatocarcinogenesis. Some ingredients of extracellular matrix such as endostatin and sulfated polysaccharide, some immunomodulatory agents and cox-2 inhibitor suppress the angiogenesis of HCC. Because vasculogenic mimicry is associated with high tumor grade, some differentiation agents are used to… CONTINUE READING
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