New strategies in acute lymphoblastic leukemia: translating advances in genomics into clinical practice.

@article{Mullighan2011NewSI,
  title={New strategies in acute lymphoblastic leukemia: translating advances in genomics into clinical practice.},
  author={Charles G Mullighan},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2011},
  volume={17 3},
  pages={
          396-400
        }
}
B-precursor acute lymphoblastic leukemia (B-ALL) is the most common childhood malignancy and remains a leading cause of death in children and young adults. Current therapeutic approaches involve intensive combination chemotherapy, which fails in up to one quarter of patients. New treatment approaches directed against rational therapeutic targets are required. Recent genomic profiling of ALL has identified several genetic alterations associated with a high risk of treatment failure. Deletion or… CONTINUE READING
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