New strategies for prevention and treatment of graft-versus-host disease and for induction of graft-versus-leukemia effects.

@article{Deeg2003NewSF,
  title={New strategies for prevention and treatment of graft-versus-host disease and for induction of graft-versus-leukemia effects.},
  author={H Joachim Deeg},
  journal={International journal of hematology},
  year={2003},
  volume={77 1},
  pages={
          15-21
        }
}
Graft-versus-host disease (GVHD) continues to be a problem in allogeneic hemopoietic stem cell transplantation; however, our understanding of the basic pathophysiology of GVHD has improved. Although not all data obtained from murine or other animal models can be extrapolated to the clinic, there are leads that deserve to be pursued. The skin, intestinal tract, and liver are the 3 major target organs of GVHD and share the feature of presenting a barrier to the "environment" of the host. There is… CONTINUE READING