New strategies for identifying gene-gene interactions in hypertension

@article{Moore2002NewSF,
  title={New strategies for identifying gene-gene interactions in hypertension},
  author={Jason H. Moore and Scott M. Williams},
  journal={Annals of Medicine},
  year={2002},
  volume={34},
  pages={88 - 95}
}
Essential hypertension is a common disease that has complex multifactorial etiology. For this reason, it is not surprising that studies of the effects of single genes on hypertension have often failed to replicate the original findings. We propose, as a working hypothesis, that the failure to replicate some single locus results is because the impact of single alleles on the risk of hypertension is dependent on genetic variations at other loci (i.e. gene-gene interactions) and on environmental… 

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