New strategic reactions for organic synthesis: catalytic asymmetric C-H activation alpha to nitrogen as a surrogate for the mannich reaction.

Abstract

The asymmetric C-H activation reactions of methyl aryldiazoacetates are readily induced by the rhodium prolinate catalyst Rh(2)(S-DOSP)(4) (1) or the bridged prolinate catalysts Rh(2)(S-biDOSP)(2) (2a) and Rh(2)(S-biTISP)(2) (2b). The C-H activation of N-Boc-protected cyclic amines demonstrates that the donor/acceptor-substituted carbenoids display… (More)

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Cite this paper

@article{Davies2003NewSR, title={New strategic reactions for organic synthesis: catalytic asymmetric C-H activation alpha to nitrogen as a surrogate for the mannich reaction.}, author={Huw M L Davies and Chandrasekar Venkataramani and Tore Hansen and D. W. Hopper}, journal={Journal of the American Chemical Society}, year={2003}, volume={125 21}, pages={6462-8} }