New steroidal nitrosoureas

@article{Chavis1982NewSN,
  title={New steroidal nitrosoureas},
  author={C. Chavis and C. D. Gourcy and Jean-Louis Borgna and Jean-Louis Imbach},
  journal={Steroids},
  year={1982},
  volume={39},
  pages={129-147}
}
  • C. Chavis, C. D. Gourcy, +1 author Jean-Louis Imbach
  • Published 1982
  • Chemistry, Medicine
  • Steroids
  • Reformatsky reaction of 3beta, 21-diacyloxy-and 3beta-methoxy-21-acyloxy-5-pregnen-20-one with ethyl bromoacetate yields, through an intramolecular 1,2-acyl migration, 38, 20 XI-diacyloxy- and 3 beta-methoxy-20 XI-acyloxy-14alpha-card-5-enolide respectively. The 20 XI-acyloxy-14, alpha-card-5-enolides were converted into the respective 20 XI-hydroxy-14alpha-card-5-enolides and the 14 alpha card-5,20(22)-dienolides. Experimental support to the proposed intramolecular 1,2-acyl migration is… CONTINUE READING
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