New sialyl Lewis(x) mimic containing an alpha-substituted beta(3)-amino acid spacer.

Abstract

A highly convergent and efficient synthesis of a new sialyl Lewis(x) (sLe(x)) mimic, which was predicted by computational studies to fulfil the spacial requirements for a selectin antagonist, has been developed. With a beta(2,3)-amino acid residue l-galactose (bioisostere of the l-fucose moiety present in the natural sLe(x)) and succinate are linked… (More)

Topics

  • Presentations referencing similar topics