New scientific paradigms for probiotics and prebiotics.

  title={New scientific paradigms for probiotics and prebiotics.},
  author={Gregor Reid and Mary Ellen Sanders and H. Rex Gaskins and Glenn R. Gibson and Annick Mercenier and R. A. Rastall and Marcel B. Roberfroid and Ian R Rowland and Christine Cherbut and Todd R. Klaenhammer},
  journal={Journal of clinical gastroenterology},
  volume={37 2},
The inaugural meeting of the International Scientific Association for Probiotics and Prebiotics (ISAPP) was held May 3 to May 5 2002 in London, Ontario, Canada. A group of 63 academic and industrial scientists from around the world convened to discuss current issues in the science of probiotics and prebiotics. ISAPP is a non-profit organization comprised of international scientists whose intent is to strongly support and improve the levels of scientific integrity and due diligence associated… 

Recent Development of Prebiotic Research—Statement from an Expert Workshop

The outcome of a workshop where academic experts working in the field of prebiotic research met with scientists from industry covered three main topics: the evolution of thePrebiotic concept/definition; the gut modeling in vitro technology PolyFermS to study prebiotics effects; and the potential novel microbiome-modulating effects associated with vitamins.

Probiotics and health – introductory comments and aim of the conference

The aim of the conference was to bring clinicians and scientists from universities and industries together for a broad and interdisciplinary definition and discussion of the state of the art regarding health effects of probiotics, especially in relation to gastric and intestinal disorders.

Health Effects of Pro- and Prebiotics: Utilization of Sophisticated In Vitro Tools

This chapter is a summary of my keynote lecture given during the International Conference on Beneficial Microbes in Penang, Malaysia, from 27 to 29 May 2014. It describes the use of sophisticated

Probiotics: delineation of prophylactic and therapeutic benefits.

Various findings suggesting their benefits in alleviating symptoms associated with aging, fatigue, and autism are listed and various claims indicating their role in reducing the risks of osteoporosis, obesity, and possibly type 2 diabetes are discussed.

Probiotics in gastrointestinal diseases.

This chapter summarizes the recommendation grades for the use of probiotics in gastroenterology according to the criteria of evidence-based medicine and indicates that new interventions will aim towards more robust modifications or remodeling of intestinal microbial populations with applications for improving gut health.

Uncovering strategies to benefit from our gut microbiota: probiotics and prebiotics

  • Á. Gil
  • Biology
    British Journal of Nutrition
  • 2013
In the present supplement, the mechanisms involving host–microbe interactions and gut immune system and oral tolerance and how gut microbiota is related to human health are reviewed and sources, isolation, characterisation and evaluation of probiotics are described.


Using yacon (Smallantus sonchifolia) is an Andean root to which prebiotics attributes have been inferred recently, and the list of prebiotic ingredients remains limited, and terminology aspects of pre- and probiotics, and their roles in human and animal health are discussed.



Urogenital Lactobacilli Probiotics, Reliability, and Regulatory Issues

A better scientific basis for specific strain use in high quality products aimed at well- defined sites is needed and information targeted at, or viewed by, consumers should state the attributes of actual strains in a given product, and reference the peer-reviewed literature.

Anti-carcinogenicity of probiotics and prebiotics.

Evidence for cancer-preventing properties of pro- and prebiotics is derived from studies on faecal enzyme activities in animals and humans, inhibition of genotoxicity of known carcinogens in vitro and In vivo, suppression of carcinogen-induced preneoplastic lesions and tumours in laboratory animals.

The use of probiotics in gastrointestinal disease.

  • K. Madsen
  • Biology
    Canadian journal of gastroenterology = Journal canadien de gastroenterologie
  • 2001
While probiotics have the potential to improve human health and to prevent and treat some diseases, major improvements are needed in labelling and quality assurance procedures for probiotic compounds.

Application of molecular biological methods for studying probiotics and the gut flora

The future of molecular biology in the field of probiotics and the gut flora will, no doubt, stretch to investigations of functionality and activity of the microflora, and/or specific fractions.

Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics.

By combining the rationale of pro- and prebiotics, the concept of synbiotics is proposed to characterize some colonic foods with interesting nutritional properties that make these compounds candidates for classification as health-enhancing functional food ingredients.

Probiotics and intestinal health effects: a clinical perspective

The evidence for the efficacy of specific probiotic strains in human gastrointestinal diseases is critically analysed and the recent randomised controlled trials performed in patients with Clostridium difficile or Helicobacter pylori, inflammatory bowel disease, irritable bowel syndrome, non-ulcer dyspepsia and colon cancer are analysed.

In situ delivery of cytokines by genetically engineered Lactococcus lactis

It is shown that mIL-10 producing L. lactis can prevent and cure enterocolitis in mice and in situ de novo synthesis of IL-10 in the colon of IL –/– mice is demonstrated.

Lactic acid bacteria as vaccine delivery vehicles

The most recent report, entitled 'Accelerated Development of Vaccines 1995' neatly summarises the background to recent advances in vaccinology, and emphasises the international perspective of these advances.

Public health issues arising from microbiological and labelling quality of foods and supplements containing probiotic microorganisms.

Improvements are needed in labelling and quality assurance procedures for products containing probiotic organisms, and the presence of the potential pathogen Enterococcus faecium in some products calls for a review of the value of this species as a probiotic.