New scavenger receptor-like receptors for the binding of lipopolysaccharide to liver endothelial and Kupffer cells.

@article{Oosten1998NewSR,
  title={New scavenger receptor-like receptors for the binding of lipopolysaccharide to liver endothelial and Kupffer cells.},
  author={Marijke van Oosten and E van de Bilt and Th J C van Berkel and J. J. W. Kuiper},
  journal={Infection and immunity},
  year={1998},
  volume={66 11},
  pages={5107-12}
}
Lipopolysaccharide (LPS) is cleared from the blood mainly by the liver. The Kupffer cells are primarily responsible for this clearance; liver endothelial and parenchymal cells contribute to a lesser extent. Although several binding sites have been described, only CD14 is known to be involved in LPS signalling. Among the other LPS binding sites that have been identified are scavenger receptors. Scavenger receptor class A (SR-A) types I and II are expressed in the liver on endothelial cells and… CONTINUE READING

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