New roles of osteoblasts involved in osteoclast differentiation.

  title={New roles of osteoblasts involved in osteoclast differentiation.},
  author={Teruhito Yamashita and Naoyuki Takahashi and Nobuyuki Udagawa},
  journal={World journal of orthopedics},
  volume={3 11},
Bone-resorbing osteoclasts are formed from a monocyte/macrophage lineage under the strict control of bone-forming osteoblasts. So far, macrophage colony-stimulating factor (M-CSF), receptor activator of nuclear factor-κB ligand (RANKL), and osteoprotegerin (OPG) produced by osteoblasts play major roles in the regulation of osteoclast differentiation. Recent studies have shown that osteoblasts regulate osteoclastogenesis through several mechanisms independent of M-CSF, RANKL, and OPG production… CONTINUE READING


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