New roles for cyclin-dependent kinases in T cell biology: linking cell division and differentiation

@article{Wells2014NewRF,
  title={New roles for cyclin-dependent kinases in T cell biology: linking cell division and differentiation},
  author={Andrew D. Wells and Peter A. Morawski},
  journal={Nature Reviews Immunology},
  year={2014},
  volume={14},
  pages={261-270}
}
The proliferation of a few antigen-reactive lymphocytes into a large population of effector cells is a fundamental property of adaptive immunity. The cell division that fuels this process is driven by signals from antigen, co-stimulatory molecules and growth factor receptors, and is controlled by the cyclin-dependent kinase (CDK) cascade. In this Opinion article, we discuss how the CDK cascade provides one potential link between cell division and differentiation through the phosphorylation of… CONTINUE READING
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