New role of phenothiazine derivatives as peripherally acting CB1 receptor antagonizing anti-obesity agents

Abstract

Developing peripherally active cannabinoid 1 (CB1) receptor antagonists is a novel therapeutic approach for the management of obesity. An unusual phenothiazine scaffold containing CB1R antagonizing hit was identified by adopting virtual screening work flow. The hit so identified was further modified by introducing polar functional groups into it to enhance… (More)
DOI: 10.1038/s41598-018-20078-w

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