New role for plasmin in sodium homeostasis.

  title={New role for plasmin in sodium homeostasis.},
  author={Christopher J. Passero and Rebecca P. Hughey and Thomas R Kleyman},
  journal={Current opinion in nephrology and hypertension},
  volume={19 1},
PURPOSE OF REVIEW Hypertension and edema are clinical manifestations of the extracellular volume expansion generated by abnormal renal sodium handling. Perturbations in epithelial sodium channel (ENaC) activity disrupt volume homeostasis. ENaC activity can be enhanced by proteases that cleave its long extracellular domains. Recent evidence suggests that this mechanism may be involved in individuals with volume overload and proteinuria. RECENT FINDINGS Several observations indicate a link… CONTINUE READING

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