New role for LEKTI in skin barrier formation: label-free quantitative proteomic identification of caspase 14 as a novel target for the protease inhibitor LEKTI.

Abstract

Lympho-epithelial Kazal-type-related inhibitor (LEKTI) is recognized as a serine protease inhibitor and is thought to play a key role in skin barrier function through the inhibition of kallikrein (KLK) activities and regulation of skin desquamation. LEKTI has a total of 15 potential inhibitory domains, and we hypothesize that it has other potential targets… (More)
DOI: 10.1021/pr1003467

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@article{Bennett2010NewRF, title={New role for LEKTI in skin barrier formation: label-free quantitative proteomic identification of caspase 14 as a novel target for the protease inhibitor LEKTI.}, author={Kate Mary Bennett and R. E. Callard and Wendy E. Heywood and John D. I. Harper and Arumugam Jayakumar and Gary L Clayman and W L Di and Kevin A Mills}, journal={Journal of proteome research}, year={2010}, volume={9 8}, pages={4289-94} }