New renin inhibitors with hydrophilic C-terminus.

  title={New renin inhibitors with hydrophilic C-terminus.},
  author={Ryszard Paruszewski and Paweł Jaworski and Iwona Winiecka and Jadwiga Tautt and Jadwiga Dudkiewicz},
  journal={Die Pharmazie},
  volume={54 2},
Four new peptide-based renin inhibitors, Boc-Phe(4-OMe)-MePhe-AHPPA-epsilon Ahx-EA (11), Boc-Phe(4-OMe)-MeLeu-AHP-PA-epsilon Ahx-EA (15), Boc-Phe(4-OMe)-MePhe-Sta-epsilon Ahx-EA (20) and Boc-Phe(4-OMe)-MeLeu-Sta-epsilon Ahx-EA (21) have been synthesized in search of structures with improved biological properties. They were designed as compounds with moderate hydrophobicity (5.28, 4.79, 4.79 and 4.30), respectively. All synthesized inhibitors were resistant to chymotrypsin activity, all were… CONTINUE READING