New regulators of NF-κB in inflammation

  title={New regulators of NF-κB in inflammation},
  author={Sankar Ghosh and Matthew S. Hayden},
  journal={Nature Reviews Immunology},
Research on the biological function of nuclear factor-κB (NF-κB), a key mediator of inducible transcription in the immune system, has traditionally focused on its role in the initiation of innate and adaptive immune responses. These studies have largely concentrated on the mechanisms of signalling that lead to NF-κB activation and on the positive role of NF-κB in both physiological immunity and pathological inflammation. More recently, there has been growing interest in the mechanisms that… CONTINUE READING
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