New regulators of NF-κB in inflammation

@article{Ghosh2008NewRO,
  title={New regulators of NF-$\kappa$B in inflammation},
  author={Sankar Kumar Ghosh and Matthew S. Hayden},
  journal={Nature Reviews Immunology},
  year={2008},
  volume={8},
  pages={837-848}
}
Research on the biological function of nuclear factor-κB (NF-κB), a key mediator of inducible transcription in the immune system, has traditionally focused on its role in the initiation of innate and adaptive immune responses. These studies have largely concentrated on the mechanisms of signalling that lead to NF-κB activation and on the positive role of NF-κB in both physiological immunity and pathological inflammation. More recently, there has been growing interest in the mechanisms that… Expand
NF-κB and the Transcriptional Control of Inflammation.
TLDR
An overview of the studies that form the basis of the understanding of the role of NF-κB subunits and their regulators in controlling inflammation is provided and the emerging importance of posttranslational modifications in the regulation of inflammation is described. Expand
NF-κB in immunobiology
TLDR
This review will focus on areas of recent progress while also providing a broad overview of the roles of NF-κB in mammalian immunobiology. Expand
Blocking NF-κB: an inflammatory issue.
TLDR
A perspective on why "dampening" rather than "abolishing" NF-κB activation may be a safe and effective treatment strategy for inflammation-associated pulmonary and other inflammatory diseases is provided. Expand
Regulation of tissue homeostasis by NF-κB signalling: implications for inflammatory diseases
TLDR
Findings indicate that NF-κB signalling acts in non-immune cells to control the maintenance of tissue immune homeostasis and prevents the pathogenesis of inflammatory diseases. Expand
NF-kappaB and the Immune System
NF-κB (nuclear factor of κB site binding) proteins are an evolutionarily conserved family of inducible transcription factors that control the expression of a large number of genes with importantExpand
Deubiquitinases in the regulation of NF-κB signaling
TLDR
Understanding the mechanisms of NF-κB downregulation by specific DUBs such as A20 and CYLD may provide therapeutic opportunities for the treatment of chronic inflammatory diseases and cancer. Expand
Tuning NF-κB activity: a touch of COMMD proteins.
TLDR
The mechanisms and proteins involved in the termination of canonical NF-κB signaling are described, with a specific focus on the role of the COMMD family in the down-modulation of NF-σκB. Expand
Tuning NF-κB: A touch of COMMd proteins
NF-κB is an important regulator of immunity and inflammation, and its activation pathway has been studied extensively. The mechanisms that downregulate the activity of NF-κB have also received a lotExpand
NF-κB and Its Regulators During Pregnancy
TLDR
The state of the art around NF-κB activity, its regulatory role in pregnancy, and the effect of its dysregulation due to invasion by pathogens like Trichomonas vaginalis and Toxoplasma gondii are described as examples. Expand
NF-κB and innate immunity.
TLDR
This review will examine signaling pathways leading to NF-κB activation during the innate immune response and mechanisms of pathogen-modulation of these pathways; the specifics of NF-σκB-dependent gene programs, and the physiological consequences for the immune system caused by the absence of individual NF-γB subunits. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 97 REFERENCES
NF-κB and the immune response
TLDR
The role of the NF-κB pathway in the development and functioning of the immune system is described and various aspects of innate and adaptive immune responses are described. Expand
Shaping the nuclear action of NF-κB
The NF-κB/REL family of transcription factors pivotally control the inflammatory and immune responses, as well as other genetic programmes that are central to cell growth and survival. TheExpand
Possible new role for NF-κB in the resolution of inflammation
TLDR
It is shown that NF-κB activation in leukocytes recruited during the onset of inflammation is associated with pro-inflammatory gene expression, whereas such activation during the resolution of inflammation was associated with the expression of anti-inflammatory genes and the induction of apoptosis. Expand
Negative Regulation of NF-κB Signaling by PIAS1
TLDR
It is reported here that PIAS1 (protein inhibitor of activated STAT1) is an important negative regulator of NF-κB, and microarray analysis indicates that the removal ofPIAS1 results in an increased expression of a subset of NF -κB-mediated genes in response to tumor necrosis factor alpha and lipopolysaccharide. Expand
Transcriptional regulation via the NF-κB signaling module
TLDR
Current understanding of the molecular structures and biochemical mechanisms that determine NF-κB dimer formation and the signal-processing characteristics of the signaling module are summarized and identified as mechanisms that generate specificity in transcriptional regulation. Expand
IκB kinase complexes: gateways to NF-κB activation and transcription
TLDR
Nuclear IKK components have been found to act directly at the chromatin level of induced genes and to mediate responses to DNA damage, and IKK is engaged in cross talk with other pathways and confers functions independently of NF-κB. Expand
IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation
TLDR
A new role for IKKα is described in the negative regulation of macrophage activation and inflammation, and the two IKK catalytic subunits have evolved opposing but complimentary roles needed for the intricate control of inflammation and innate immunity. Expand
Negative Regulation of Toll-Like Receptor Signaling by NF-κB p50 Ubiquitination Blockade
TLDR
The identification of B cell leukemia (Bcl)–3 as an essential negative regulator of TLR signaling is reported, indicating that the p50 ubiquitination pathway can be selectively targeted to control deleterious inflammatory diseases. Expand
Shared Principles in NF-κB Signaling
TLDR
This work attempts to synthesize some of the basic principles that have emerged from studies of NF-kappaB, and aims to generate a more unified view ofNF- kappaB regulation. Expand
...
1
2
3
4
5
...