New recurring cytogenetic abnormalities and association of blast cell karyotypes with prognosis in childhood T-cell acute lymphoblastic leukemia: a pediatric oncology group report of 343 cases.

@article{Schneider2000NewRC,
  title={New recurring cytogenetic abnormalities and association of blast cell karyotypes with prognosis in childhood T-cell acute lymphoblastic leukemia: a pediatric oncology group report of 343 cases.},
  author={Nancy R. Schneider and Andrew J. Carroll and Jonathan J Shuster and Daniel Pullen and Michael P. Link and Michael J. Borowitz and Bruce M. Camitta and Jeffry A. Katz and Michael D. Amylon},
  journal={Blood},
  year={2000},
  volume={96 7},
  pages={2543-9}
}
To further define the cytogenetic differences between B-cell lineage (B-lineage) acute lymphoblastic leukemia (ALL) and T-cell lineage ALL (T-ALL) and to determine the prognostic value of cytogenetics in childhood T-ALL, the blast cell karyotypes of 343 cases of pediatric T-ALL, the largest series reported to date, were evaluated. Cytogenetics were performed in a single central laboratory, and the children were treated using a single Pediatric Oncology Group protocol. Clear differences between… CONTINUE READING