New rat model induced by anti-glomerular basement membrane antibody shows severe glomerular adhesion in early stage and quickly progresses to end-stage renal failure.

@article{Nakano2008NewRM,
  title={New rat model induced by anti-glomerular basement membrane antibody shows severe glomerular adhesion in early stage and quickly progresses to end-stage renal failure.},
  author={Yoshimasa Nakano and Takahiro Hirano and Kenji Uehara and Seiji Nishibayashi and Katsuji Hattori and Miki Aihara and Yoshihisa Yamada},
  journal={Pathology international},
  year={2008},
  volume={58 6},
  pages={
          361-70
        }
}
The aim of the present study was to introduce a new anti-glomerular basement membrane nephritis model in which plasma creatinine levels dramatically increased only 4 weeks after a single administration of rabbit antirat glomerular basement membrane antibody in Sprague-Dawley rats. According to renal morphology, glomerular lesions characterized by mesangial expansion and adhesion of the glomerular tuft to Bowman's capsule were observed in the early stage at day 7 after disease induction… CONTINUE READING

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