New putative selective agonists at the D-1 dopamine receptor: Behavioural and neurochemical comparison of CY 208-243 with SK&F 101384 and SK&F 103243

@article{Murray1990NewPS,
  title={New putative selective agonists at the D-1 dopamine receptor: Behavioural and neurochemical comparison of CY 208-243 with SK\&F 101384 and SK\&F 103243},
  author={A. M. Murray and J. Waddington},
  journal={Pharmacology Biochemistry and Behavior},
  year={1990},
  volume={35},
  pages={105-110}
}
Three putative D-1 agonists with nonbenzazepine structures were compared with the prototype benzazepine D-1 partial agonist SK&F 38393 for their behavioural effects in the intact adult rat, and for their relative affinities for D-1 and D-2 dopamine receptors in vitro. SK&F 103243, a restricted conformation analogue of SK&F 38393, and SK&F 101384 (8-Cl-ADTN) showed low affinity for D-1 and D-2 receptors in in vitro binding studies, and failed to induce any behavioural effects on peripheral… Expand
Motor depression: A new role for D1 receptors?
CY 208–243 behaves as a typical D-1 agonist in the reserpine-treated mouse
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