New prodrugs against tuberculosis.

@article{Mori2017NewPA,
  title={New prodrugs against tuberculosis.},
  author={Giorgia Mori and Laurent Roberto Chiarelli and Giovanna Riccardi and Maria Rosalia Pasca},
  journal={Drug discovery today},
  year={2017},
  volume={22 3},
  pages={519-525}
}
The term 'prodrug' was first introduced by Albert in 1958. Generally, prodrugs can be utilized for improving active drug solubility and bioavailability, increasing drug permeability and absorption, modifying the distribution profile, preventing fast metabolism and excretion, and reducing toxicity. Previously, the prodrug approach was a final resort during the drug discovery process only after all other approaches had been exhausted. However, this strategy is now considered during the early… CONTINUE READING

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Most antitubercular agents are defined as ' prodrugs ' , including isoniazid and ethionamide .
Most antitubercular agents are defined as ' prodrugs ' , including isoniazid and ethionamide .
Most antitubercular agents are defined as ' prodrugs ' , including isoniazid and ethionamide .
Most antitubercular agents are defined as ' prodrugs ' , including isoniazid and ethionamide .
Most antitubercular agents are defined as ' prodrugs ' , including isoniazid and ethionamide .
Most antitubercular agents are defined as ' prodrugs ' , including isoniazid and ethionamide .
Most antitubercular agents are defined as ' prodrugs ' , including isoniazid and ethionamide .
Most antitubercular agents are defined as ' prodrugs ' , including isoniazid and ethionamide .
Most antitubercular agents are defined as ' prodrugs ' , including isoniazid and ethionamide .
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