New pregnane and phenolic glycosides from Solenostemma argel.


From the aerial parts, pericarps and roots of Solenostemma argel, three new pregnane glycosides (1-3) with two known ones and a new phenolic glycoside (4) have been isolated. Their structures were established by extensive 1D - and 2D NMR and mass spectroscopic analysis. The cytotoxicity of all compounds was evaluated against two human tumor cell lines (SW 480, MCF-7), but none of them was active in the concentration range 0.9-59.0μM. Compounds 2 and the known argeloside F at non toxic concentrations for the PBMCs (27.3μM and 27.6μM, respectively) significantly decreased the Il-1β production by LPS-stimulated PBMCs. All isolated compounds showed a significant antioxidant potential with ORAC values in the concentration range 3481-9617μmoleq. Trolox/100g.

DOI: 10.1016/j.fitote.2016.08.002

Cite this paper

@article{Ounaissia2016NewPA, title={New pregnane and phenolic glycosides from Solenostemma argel.}, author={Karima Ounaissia and David Pertuit and Anne-Claire Mitaine-Offer and Tomofumi Miyamoto and Chiaki Tanaka and St{\'e}phanie Delemasure and Patrick Dutartre and Dalila Smati and Marie-Aleth Lacaille-Dubois}, journal={Fitoterapia}, year={2016}, volume={114}, pages={98-104} }