New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights.

@article{LpezRamos2010NewPD,
  title={New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights.},
  author={Miriam L{\'o}pez-Ramos and Renaud Prudent and Virginie Moucadel and C{\'e}line F. Sautel and Caroline Barette and Laurence Lafanech{\`e}re and Liliane Mouawad and David Grierson and Fr{\'e}d{\'e}ric Schmidt and Jean-Claude Florent and Panagis Filippakopoulos and Alex N Bullock and Stefan Knapp and J. Reiser and Claude Cochet},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2010},
  volume={24 9},
  pages={3171-85}
}
Protein kinase casein kinase 2 (CK2) is a serine/threonine kinase with evidence of implication in growth dysregulation and apoptosis resistance, making it a relevant target for cancer therapy. Several CK2 inhibitors have been developed showing variable efficiency, emphasizing the need to expand the chemical diversity of those inhibitors. We report the identification and characterization of 2,8-difurandicarboxylic acid derivatives as a new class of nanomolar ATP-competitive inhibitors… CONTINUE READING