New players and puzzles in the Hedgehog signaling pathway.

  title={New players and puzzles in the Hedgehog signaling pathway.},
  author={Randy L. Johnson and Matthew P Scott},
  journal={Current opinion in genetics & development},
  volume={8 4},
Members of the Hedgehog (Hh) family of signaling proteins control cell fates and proliferation during animal development in part by regulating the transcription of specific genes. Depending on the tissue, Hh can act over long or short distances, to signal directly or by inducing secondary signals. Recent discoveries include new components of the pathway as well as novel regulatory mechanisms involving cholesterol, proteolysis, and the cytoskeleton. The role of Hh in carcinogenesis is… CONTINUE READING

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