New photostable naphthalimide-based fluorescent probe for mitochondrial imaging and tracking.

@article{Huang2015NewPN,
  title={New photostable naphthalimide-based fluorescent probe for mitochondrial imaging and tracking.},
  author={Saipeng Huang and Rongcheng Han and Qianfen Zhuang and Libo Du and Hongying Jia and Yangping Liu and Yang P. Liu},
  journal={Biosensors & bioelectronics},
  year={2015},
  volume={71},
  pages={
          313-321
        }
}
Monitoring mitochondria morphological changes temporally and spatially exhibits significant importance for diagnosing, preventing and treating various diseases related to mitochondrial dysfunction. However, the application of commercially available mitochondria trackers is limited due to their poor photostability. To overcome these disadvantages, we designed and synthesized a mitochondria-localized fluorescent probe by conjugating 1,8-naphthalimide with triphenylphosphonium (i.e. NPA-TPP). The… CONTINUE READING