New pharmacological treatment strategies for relapse prevention.

@article{Spanagel2013NewPT,
  title={New pharmacological treatment strategies for relapse prevention.},
  author={Rainer Spanagel and Valentina Vengeliene},
  journal={Current topics in behavioral neurosciences},
  year={2013},
  volume={13},
  pages={
          583-609
        }
}
Here we discuss treatment strategies that are based on pharmacological interventions to reduce craving and relapse in alcohol-dependent patients. We will first provide a historical overview about relapse prevention strategies. We will then review the development of disulfiram, naltrexone, acamprosate, and nalmefene and discuss their neurobiological modes of action. Then the concept of convergent genomic analysis will be introduced for the discovery of new molecular treatment targets. Finally… CONTINUE READING
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