New pharmacological approaches for obesity management

@article{RuedaClausen2013NewPA,
  title={New pharmacological approaches for obesity management},
  author={Christian F. Rueda-Clausen and Raj S. Padwal and Arya M. Sharma},
  journal={Nature Reviews Endocrinology},
  year={2013},
  volume={9},
  pages={467-478}
}
Obesity, which results from an imbalance between calorie intake and expenditure, now affects over 500 million individuals worldwide. Lifestyle and behavioural interventions aimed at reducing calorie intake and/or increasing energy expenditure have limited long-term effectiveness due to complex and persistent hormonal, metabolic and neurochemical adaptations that defend against weight loss and promote weight regain. Surgical treatments for obesity, although highly effective, are unavailable or… 

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