New perspectives on the role of SERCA2's Ca2+ affinity in cardiac function.

@article{Vangheluwe2006NewPO,
  title={New perspectives on the role of SERCA2's Ca2+ affinity in cardiac function.},
  author={Peter Vangheluwe and Karin Sipido and Luc Raeymaekers and Frank Wuytack},
  journal={Biochimica et biophysica acta},
  year={2006},
  volume={1763 11},
  pages={1216-28}
}
Cardiomyocyte relaxation and contraction are tightly controlled by the activity of the cardiac sarco(endo)plasmic reticulum (SR) Ca2+ transport ATPase (SERCA2a). The SR Ca2+ -uptake activity not only determines the speed of Ca(2+) removal during relaxation, but also the SR Ca2+ content and therefore the amount of Ca2+ released for cardiomyocyte contraction. The Ca2+ affinity is the major determinant of the pump's activity in the physiological Ca2+ concentration range. In the heart, the affinity… CONTINUE READING
21 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 21 extracted citations

Similar Papers

Loading similar papers…