New perspectives on immunomodulatory therapy for bacteraemia and sepsis.

@article{Opal2010NewPO,
  title={New perspectives on immunomodulatory therapy for bacteraemia and sepsis.},
  author={Steven M. Opal},
  journal={International journal of antimicrobial agents},
  year={2010},
  volume={36 Suppl 2},
  pages={S70-3}
}
Systemic immune dysregulation is generally acknowledged to be the fundamental molecular mechanism that underlies the pathophysiology of severe sepsis and septic shock. In the presence of a systemic infection, microbial pathogens and their soluble mediators induce generalised immune activation and coagulation activation, leading to severe sepsis and septic shock. For decades, immune-based therapies have been devised with the specific intent of inhibiting the pro-inflammatory events that are… CONTINUE READING

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