New perspectives on folate transport in relation to alcoholism‐induced folate malabsorption – association with epigenome stability and cancer development

@article{Hamid2009NewPO,
  title={New perspectives on folate transport in relation to alcoholism‐induced folate malabsorption – association with epigenome stability and cancer development},
  author={Abid Hamid and Nissar Ahmad Wani and Jyotdeep Kaur},
  journal={The FEBS Journal},
  year={2009},
  volume={276}
}
Folates are members of the B‐class of vitamins, which are required for the synthesis of purines and pyrimidines, and for the methylation of essential biological substances, including phospholipids, DNA, and neurotransmitters. Folates cannot be synthesized de novo by mammals; hence, an efficient intestinal absorption process is required. Intestinal folate transport is carrier‐mediated, pH‐dependent and electroneutral, with similar affinity for oxidized and reduced folic acid derivatives. The… Expand
View on Wiley
ncbi.nlm.nih.gov
127 Citations
Highly Influential Citations
5
Background Citations
46
Methods Citations
2

127 Citations

Citation Type

Citation Type

The Concept of Folic Acid in Health and Disease
TLDR
Food folic acid fortification was introduced in many countries because of the observational data that folates have a protective effect against neural tube defects, ischemic events, and cancer, however, high physiological folate concentrations and folate overload may increase the risk of impaired brain development in embryogenesis. Expand
Biochemical and Molecular Mechanisms of Folate Transport in Rat Pancreas; Interference with Ethanol Ingestion
TLDR
The present study deals with the mechanistic insights of reduced folate absorption in pancreas during chronic alcoholism by studying the mechanisms of alcohol associated reduced folates uptake in male Wistar rats. Expand
Decreased activity of folate transporters in lipid rafts resulted in reduced hepatic folate uptake in chronic alcoholism in rats
TLDR
The chronic ethanol ingestion led to decreased folate uptake in liver, which was associated with the decreased number of transporter molecules in the lipid rafts that can be ascribed to the reduced synthesis of these transporters. Expand
Folate malabsorption is associated with down-regulation of folate transporter expression and function at colon basolateral membrane in rats.
TLDR
The mechanistic insights of folate malabsorption in colonic basolateral membrane (BLM) are dealt with, which shows characteristics of carrier-mediated process with the major involvement of reduced folate carrier (RFC). Expand
Alcohol-associated folate disturbances result in altered methylation of folate-regulating genes
TLDR
The results showed that there was not any significant change in the activity of folate hydrolyzing enzyme GGH in ethanol-fed rats while there was significant down regulation in the expression of FPGS. Expand
Identification of regulatory mechanisms of intestinal folate transport in condition of folate deficiency.
TLDR
Increased expression of transporters under FD conditions can be attributed to enhanced rate of transcription of folate transporter and also to the increased binding of specificity protein 1 transcription factor to the RFC promoter only. Expand
Adaptive transport of folic acid across renal epithelia in folate-deficient rats
  • N. Wani, J. Kaur
  • Medicine, Biology
  • The Journal of Physiological Sciences
  • 2012
TLDR
Folate deficiency increased the renal brush border membrane and basolateral folate uptake by increasing the number of transporter molecules and the observed up-regulation of mRNA expression was also associated with a significant increase in RFC and PCFT expression at the protein level. Expand
Regulatory mechanisms of intestinal folate uptake in a rat model of folate oversupplementation
TLDR
It was concluded that acute folate oversupplementation results in a significant decrease in intestinal folate uptake by down-regulating the expressions of RFC and PCFT, via some post-transcriptional or translational mechanisms. Expand
Genetic aspects of folate metabolism.
  • A. Molloy
  • Biology, Medicine
  • Sub-cellular biochemistry
  • 2012
TLDR
There is increasing research into the importance of folate-derived one-carbon units for DNA and histone methylation reactions, which exert crucial epigenetic control over cellular protein synthesis. Expand
Mechanism of intestinal folate transport during folate deficiency in rodent model
TLDR
The observed upregulation was associated with significant increase in reduced folate carrier (RFC) and proton coupled folate transporter (PCFT) expressions, suggesting the transcriptional and translational regulation of folate uptake during folate deficiency. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 154 REFERENCES
The folate cycle and disease in humans.
  • B. Fowler
  • Biology, Medicine
  • Kidney international. Supplement
  • 2001
The prevalence of hyperhomocysteinemia in renal disease patients, its treatment by folate administration, and its aggravation by the 677 C-->T mutation of methylene-tetrahydrofolate (methylene-THF)… Expand
Identification of an Intestinal Folate Transporter and the Molecular Basis for Hereditary Folate Malabsorption
TLDR
It is established that a major function of this gene product is proton-coupled folate transport required for folate homeostasis in man, and the name is amended to PCFT/HCP1. Expand
Down‐regulation of reduced folate carrier may result in folate malabsorption across intestinal brush border membrane during experimental alcoholism
TLDR
The low folate uptake activity observed in ethanol‐fed rats was found to be associated with decreased serum and red blood cell folate levels, which might explain the observed jejunal genomic hypomethylation and offer possible mechanistic insights into folate malabsorption during alcoholism. Expand
Effect of folate oversupplementation on folate uptake by human intestinal and renal epithelial cells.
TLDR
Long-term oversupplementation with folate leads to a specific and significant down-regulation in intestinal and renal folate uptake, which is associated with a decrease in message levels of hRFC, PCFT/HCP1, and FR. Expand
Molecular and cellular biology of the human reduced folate carrier.
  • L. Matherly
  • Biology, Medicine
  • Progress in nucleic acid research and molecular biology
  • 2001
TLDR
The results of research into the human reduced folate carrier should clarify the roles of changes in expression and function of this system that accompany nutritional folate deficiency and human disease, and may lead to improved therapeutic strategies for enhancing drug response and circumventing resistance in cancer patients undergoing chemotherapy with antifolates. Expand
Adaptive regulation of intestinal folate uptake: effect of dietary folate deficiency.
TLDR
It is demonstrated, for the first time, that dietary folate deficiency leads to a marked upregulation in intestinal folate uptake and in the activity of folate hydrolase. Expand
New perspectives on folate catabolism.
TLDR
Folate catabolism is emerging as an important component in the regulation of intracellular folate concentrations and whole-body folate status and ferritin levels are elevated in most physiological states associated with increased folateCatabolism. Expand
Effects of alcohol on folate metabolism: implications for carcinogenesis.
TLDR
Epidemiologic observations implicate excess ethanol ingestion as well as low dietary folate intake as risk factors for several cancers and support the concept of a synergistic effect between these two factors. Expand
Reduced folate carrier: tissue distribution and effects of chronic ethanol intake in the micropig.
TLDR
It is suggested that chronic ethanol exposure decreases the intestinal absorption of folic acid by altering the expression of RFC and consequently its transport kinetics in JBB, providing a mechanism for the clinical finding of reduced folic Acid absorption in chronic alcoholics. Expand
Evaluation of the kinetic properties of the folate transport system in intestinal absorptive epithelium during experimental ethanol ingestion
TLDR
The findings suggest that the deregulated folate transport kinetics might contribute to intestinal folate malabsorption in alcoholism. Expand
...
1
2
3
4
5
...