New perspectives on folate transport in relation to alcoholism‐induced folate malabsorption – association with epigenome stability and cancer development

@article{Hamid2009NewPO,
  title={New perspectives on folate transport in relation to alcoholism‐induced folate malabsorption – association with epigenome stability and cancer development},
  author={Abid Hamid and Nissar Ahmad Wani and Jyotdeep Kaur},
  journal={The FEBS Journal},
  year={2009},
  volume={276}
}
Folates are members of the B‐class of vitamins, which are required for the synthesis of purines and pyrimidines, and for the methylation of essential biological substances, including phospholipids, DNA, and neurotransmitters. Folates cannot be synthesized de novo by mammals; hence, an efficient intestinal absorption process is required. Intestinal folate transport is carrier‐mediated, pH‐dependent and electroneutral, with similar affinity for oxidized and reduced folic acid derivatives. The… Expand
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