New perspectives of valproic acid in clinical practice

@article{Cincarova2013NewPO,
  title={New perspectives of valproic acid in clinical practice},
  author={L. Cincarova and Z. Zdr{\'a}hal and J. Fajkus},
  journal={Expert Opinion on Investigational Drugs},
  year={2013},
  volume={22},
  pages={1535 - 1547}
}
  • L. Cincarova, Z. Zdráhal, J. Fajkus
  • Published 2013
  • Medicine
  • Expert Opinion on Investigational Drugs
  • Introduction: Valproic acid (VPA) has been used in clinical practice as an anticonvulsant for more than four decades. Its pharmacokinetics and toxicity are thus well documented. VPA is also a potent class-selective histone deacetylase (HDAC) inhibitor at nontoxic therapeutic concentrations. New areas of application for VPA are currently opening up in clinical practice. Areas covered: The authors discuss VPA and how it may serve as an effective drug for cancer therapy. This is due to its ability… CONTINUE READING
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