New perspectives of physiological and pathological functions of nucleolin (NCL).

  title={New perspectives of physiological and pathological functions of nucleolin (NCL).},
  author={Wenyu Jia and Zhenyu Yao and Jiajun Zhao and Qingbo Guan and Ling Gao},
  journal={Life sciences},
Nucleolin (NCL) is a multifunctional protein that mainly localized in the nucleolus, it is also found in the nucleoplasm, cytoplasm and cell membrane. The three main structural domains allow the interaction of NCL with different proteins and RNA sequences. Moreover, specific post-translational modifications and its shuttling property also contribute to its multifunctionality. NCL has been demonstrated to be involved in a variety of aspects such as ribosome biogenesis, chromatin organization and… CONTINUE READING
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