New perspectives in the functional role of GABAa channel heterogeneity

  title={New perspectives in the functional role of GABAa channel heterogeneity},
  author={S. Vicini},
  journal={Molecular Neurobiology},
  • S. Vicini
  • Published 2007
  • Medicine, Biology
  • Molecular Neurobiology
  • Abstractγ-Aminobutyric acid A (GABAA) channels responsible for inhibitory synaptic transmission possess a consistent heterogeneity of structure in terms of distinct constitutive subunits. During the past 10 years, considerable progress has been made in understanding the magnitude of this large diversity. Structural requirements for clinically important drugs such as benzodiazepines and barbiturates have been elucidated, and the anatomical distribution in distinct neuronal populations and the… CONTINUE READING

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