New perspectives in glioblastoma antiangiogenic therapy

  title={New perspectives in glioblastoma antiangiogenic therapy},
  author={Alisa Madalina Popescu and Stefana Oana Purcaru and Oana Alexandru and Anica Dricu},
  booktitle={Contemporary oncology},
Glioblastoma (GB) is highly vascularised tumour, known to exhibit enhanced infiltrative potential. One of the characteristics of glioblastoma is microvascular proliferation surrounding necrotic areas, as a response to a hypoxic environment, which in turn increases the expression of angiogenic factors and their signalling pathways (RAS/RAF/ERK/MAPK pathway, PI3K/Akt signalling pathway and WTN signalling cascade). Currently, a small number of anti-angiogenic drugs, extending glioblastoma patients… CONTINUE READING
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