New perspectives: systems medicine in cardiovascular disease

@article{Kramer2018NewPS,
  title={New perspectives: systems medicine in cardiovascular disease},
  author={Frank Kramer and Steffen Just and Tanja Zeller},
  journal={BMC Systems Biology},
  year={2018},
  volume={12}
}
BackgroundCardiovascular diseases (CVD) represent one of the most important causes of morbidity and mortality worldwide. Innovative approaches to increase the understanding of the underpinnings of CVD promise to enhance CVD risk assessment and might pave the way to tailored therapies. Within the last years, systems medicine has emerged as a novel tool to study the genetic, molecular and physiological interactions.ConclusionIn this review, we provide an overview of the current molecular… 
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References

SHOWING 1-10 OF 129 REFERENCES
Systems Medicine as an Emerging Tool for Cardiovascular Genetics
TLDR
This review provides an overview about the current approaches for systems medicine in CVD, including bioinformatical and experimental tools such as cell and animal models, omics technologies, network, and pathway analyses.
Systems-based approaches to cardiovascular disease
TLDR
An overview of systems-based approaches to cardiovascular disease is provided and their translational implications are discussed.
Systems biology and the future of medicine
TLDR
Quantitative, holistic systems biology applied to human disease offers a unique approach for diagnosing established disease, defining disease predilection, and developing individualized (personalized) treatment strategies that can take full advantage of modern molecular pathobiology and the comprehensive data sets that are rapidly becoming available for populations and individuals.
Systems Medicine: The Application of Systems Biology Approaches for Modern Medical Research and Drug Development
TLDR
Systems medicine approaches can be employed for shedding light in multiple research scenarios, ultimately leading to the practical result of uncovering novel dynamic interaction networks that are critical for influencing the course of medical conditions.
Large animal models of cardiovascular disease
TLDR
This work has shown that novel systems provide a huge potential for large animal models to investigate the regulatory factors and molecular pathways that contribute to CVD in vivo and will help bridge the gap between basic science and clinical applications by facilitating the refinement of therapies for cardiovascular disease.
Novel Risk Markers and Risk Assessments for Cardiovascular Disease
TLDR
Recent large sample-size studies that have been validated in a separate cohort in most cases are focused on, highlighting the prognostic ability of risk markers related to atherosclerosis, thrombosis, inflammation, cardiac injury, and fibrosis.
Systems medicine: evolution of systems biology from bench to bedside
TLDR
Systems biology is evolving to systems medicine as a new discipline that aims to offer new approaches for addressing the diagnosis and treatment of major human diseases uniquely, effectively, and with personalized precision.
Fishing for the genetic basis of cardiovascular disease
TLDR
Cardiovascular zebrafish models provide the opportunity to develop and test novel therapeutic strategies, using innovative technologies such as high throughput in vivo small molecule screens, and allow the unbiased identification of novel and unanticipated cardiovascular genes.
...
...