New penicillide derivatives isolated from Penicillium simplicissimum

  title={New penicillide derivatives isolated from Penicillium simplicissimum},
  author={Shin-ichirou Komai and Tomoo Hosoe and Takeshi Itabashi and Koohei Nozawa and Takashi Yaguchi and Kazutaka Fukushima and Ken-ichi Kawai},
  journal={Journal of Natural Medicines},
Two new penicillide derivatives, secopenicillides A (3) and B (4), were isolated along with penicillide (1) and purpactin A (2), and altenusin (5) and dehydroaltenusin (6), the antifungal substances of this fungus, from the extract of Penicillium simplicissimum IFM 53375. The absolute structures of 3 and 4 were determined by spectroscopic investigation and chemical correlation to penicillide (1). The absolute configuration of purpactin A (2) was determined by the chemical method. 

Three new polyketides from the endophytic fungus Penicillium purpurogenum

Abstract Three new polyketides including two benzophenone derivatives, penibenzones A and B (1 and 2), and a new phthalide derivative, penibenzone C (3), along with six known compounds, were isolated

Azaphilone and Diphenyl Ether Derivatives from a Gorgonian-Derived Strain of the Fungus Penicillium pinophilum.

Three new azaphilone derivatives, pinophilins D-F (1-3), and one new diphenyl ether derivative, hydroxypenicillide (10), together with nine known compounds, were isolated from the gorgonian-derived fungus PenicilliumPinophilum XS-20090E18 and showed cytotoxicity against Hep-2, RD, and HeLa cell lines.

Penixanthones A and B, two new xanthone derivatives from fungus Penicillium sp. SYFz-1 derived of mangrove soil sample

Abstract Two new xanthone derivatives, penixanthones A (1) and B (2), together with three known compounds, aspenicillide (3), 1,5-dihydroxy-3-methoxy-7-methyl-anthracene-9,10-dione (4) and

Penicillanthone and penicillidic acids A–C from the soil-derived fungus Penicillium aculeatum PSU-RSPG105

Altenusin (12) displayed moderate antibacterial activity against methicillin-resistant Staphylococcus aureus with an MIC value of 32 μg mL−1 and mild activity towards Vero cells with an IC50 value of 19.46 μM.

A new bioactive isocoumarin from the mangrove-derived fungus Penicillium sp. TGM112

Abstract A new isocoumarin, penicimarin N (1), along with five known compounds (2-6), were isolated from the mangrove-derived fungus Penicillium sp. TGM112. The structure of 1 was elucidated on the

New Cytotoxic Metabolites from the Marine‐Derived Fungus Penicillium sp. ZLN29

One new penicillide derivative, prenpenicillide (1), and one new xanthone derivative, prenxanthone (2), were isolated from the culture extract of the marine-derived fungus Penicillium sp. ZLN29,

Polyketides and Meroterpenoids from Neosartorya glabra

Two new polyketides, neosarphenols A and B (1 and 2, resp.), were isolated from Neosartorya glabra, together with six known polyketides, 3–8, and two meroterpenoids, 9 and 10. The structures of the



New Vermistatin Derivatives Isolated from Penicillium simplicissimum

Four new vermistatin derivatives, dihydrovermistatin (1), acetoxydihydrovermistatin (2), hydroxydihydrovermistatin (3), and penisimplicissin (4) were isolated along with vermistatin (5), penicillide,

Two new meroterpenoids, penisimplicin A and B, isolated from Penicillium simplicissimum.

In the course of the research for new antifungal agents, two new meroterpenoids, penisimplicin A and B (2), were isolated from Penicillium simplicissimum and showed no antIFungal activities.

Purpactins, new inhibitors of acyl-CoA:cholesterol acyltransferase produced by Penicillium purpurogenum. I. Production, isolation and physico-chemical and biological properties.

Penicillium purpurogenum FO-608, a soil isolate, was found to produce a series of new inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT), indicating the inhibition of ACAT activity in the living cells by purpactin A.

Purpactins, new inhibitors of acyl-CoA:cholesterol acyltransferase produced by Penicillium purpurogenum. II. Structure elucidation of purpactins A, B and C.

The structure of purpactins, novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors, was determined by spectroscopic analyses by deducing the identity of 1'-O-acetylpenicillide.

Studies in the biochemistry of micro-organisms. 103. Metabolites of Alternaria tenuis auct; culture filtrate products.

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A laboratory guide to common Penicillium species

Vermixocins A and B, two novel metabolites from Penicillium vermiculatum.

Both metabolites showed cytotoxic effects on lympholeukemia cells P388, and were isolated from the mycelium of Penicillium vermiculatum.