New pattern of EGFR amplification in glioblastoma and the relationship of gene copy number with gene expression profile

@article{LpezGins2010NewPO,
  title={New pattern of EGFR amplification in glioblastoma and the relationship of gene copy number with gene expression profile},
  author={Concha L{\'o}pez-Gin{\'e}s and Rosario Gil-Benso and Rub{\'e}n Ferrer-Luna and R. Garcı́a Benito and Eva Serna and Jos{\'e} Manuel Gonz{\'a}lez-Darder and Vicente Quilis and Daniel Monleon and Bernardo Celda and Miguel Cerd{\'a}-nicol{\'a}s},
  journal={Modern Pathology},
  year={2010},
  volume={23},
  pages={856-865}
}
Gene amplification is a process that is characterized by an increase in the copy number of a restricted region in a chromosome arm, and is frequently associated with an overexpression of the corresponding amplified gene. Amplified DNA can be organized either as extrachromosomal elements, repeated units at a single locus or scattered throughout the genome. The amplification of the gene for epidermal growth factor receptor (EGFR) is a common finding in glioblastomas and the amplified gene copies… CONTINUE READING