New pathway links from cancer-progression determinants to gene expression of matrix metalloproteinases in breast cancer cells.

@article{Delassus2008NewPL,
  title={New pathway links from cancer-progression determinants to gene expression of matrix metalloproteinases in breast cancer cells.},
  author={Gregory S Delassus and Hyojin Cho and Janice Park and George L Eliceiri},
  journal={Journal of cellular physiology},
  year={2008},
  volume={217 3},
  pages={739-44}
}
AP-2alpha, interleukin-4 (IL-4), E-cadherin, fibulin 1D, p16(INK4alpha), PTEN, RKIP, and S100A4 are determinants (suppressors, except for S100A4) of cancer cell invasiveness and other traits of cancer progression, which are located upstream of matrix metalloproteinases (MMPs) in cell signaling pathways. We will refer to them as upstream cancer-progression determinants (UCPDs, for brevity). MMP-1, MMP-2, MMP-9, MMP-11, MMP-13, MMP-14, MMP-16, and MMP-19 are enhancers of cancer cell invasiveness… CONTINUE READING

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