New paths to pain relief

@article{Brower2000NewPT,
  title={New paths to pain relief},
  author={Vicki Brower},
  journal={Nature Biotechnology},
  year={2000},
  volume={18},
  pages={387-391}
}
  • V. Brower
  • Published 1 April 2000
  • Medicine
  • Nature Biotechnology
A better understanding of the mechanisms by which pain signals are relayed in the nervous system is paving the way for novel treatments. 
Attacking pain at its source: new perspectives on opioids
The treatment of severe pain with opioids has thus far been limited by their unwanted central side effects. Recent research promises new approaches, including opioid analgesics acting outside the
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Targeting of immune cells containing opioids to injured tissues is a novel concept of pain control and opens potential new therapeutic approaches.
Peripheral mechanisms of pain and analgesia
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The identification and cloning of the vanilloid receptor TRPV1 represents a significant step in the clarification of the molecular mechanisms underlying transduction of noxious chemical and thermal stimuli by peripheral nociceptors.
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The research team found an effective strategy in treating neuropathic pain that resulted from interactions between leukocyte-derived opioid peptides and their receptors on peripheral sensory neurons, and proved that G-CSF can increase the number of opioid-contained polymorphonuclear cells and significantly relieve neuropathicPain.
Insight into Pain Modulation: Nociceptors Sensitization and Therapeutic Targets.
TLDR
This review mainly focused on various classes of nociceptors involved in pain transduction, transmission and modulation, site of action of the nocICEptors in modulating pain transmission pathways and the drugs (both clinical and preclinical data, relevant to targets) alleviating the painful stimuli by exploiting noc iceptor-specific channels and receptors.
Emerging therapeutic strategies for chronic pain
TLDR
The physiological processes occurring in chronic pain is outlined, some of the approaches recently developed and a number of drugs currently under development that aim to provide safer and more effective analgesia for chronic pain are mentioned.
Peripheral analgesic and anti-inflammatory effects of opioids — neuro-immune crosstalk
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This work presents an entirely new field, the selective targeting of opioid peptide-containing cells to sites of painful tissue injury and the augmentation of opioid synthesis by gene transfer, which opens exciting prospects for future therapeutic approaches.
Polymer-Based Biodegradable Drug Delivery Systems in Pain Management
TLDR
An overview of the biodegradable polymers that are used in drug delivery systems is presented and an experience in developing a device for multimodal drug delivery, including the use of nanotechnology is referred to.
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