New pathogenic paradigms in inflammatory bowel disease.

  title={New pathogenic paradigms in inflammatory bowel disease.},
  author={Antonio Di Sabatino and Paolo Biancheri and Laura Rovedatti and Thomas Macdonald and Gino R Corazza},
  journal={Inflammatory bowel diseases},
  volume={18 2},
Recent progresses in basic science have opened new pathogenic scenarios in inflammatory bowel disease. The T helper cell type (Th)1/Th2 paradigm has been outdated thanks to the advances in understanding the function of Th17 cells. Innate immunity, nonimmune cells, and defective tolerogenic mechanisms play a no less crucial role than do adaptive immunity, immune cells, and hyperactivation of effector mechanisms. These new paradigms, together with the no longer "static" but "dynamic" vision of… CONTINUE READING
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