New paradigms for HIV/AIDS vaccine development.

  title={New paradigms for HIV/AIDS vaccine development.},
  author={Louis J. Picker and Scott G Hansen and Jeffrey D Lifson},
  journal={Annual review of medicine},
HIV-1 and its simian counterpart SIV have been exquisitely tailored by evolution to evade host immunity. By virtue of specific adaptations that thwart individual innate or adaptive immune mechanisms, and an overall replication strategy that provides for rapid establishment of a large, systemic viral population, capable of dynamic adaptation to almost all immune selection pressures, these viruses, once established, almost invariably stay one step ahead of the host's immune system, and in the… CONTINUE READING