New p32/gC1qR Ligands for Targeted Tumor Drug Delivery.

@article{Paasonen2016NewPL,
  title={New p32/gC1qR Ligands for Targeted Tumor Drug Delivery.},
  author={Lauri Paasonen and Sunita Sharma and Gary B Braun and Venkata Ramana Kotamraju and Thomas D Y Chung and Zhi-gang She and Kazuki N. Sugahara and Marjo L Yliperttula and Bainan Wu and Maurizio Pellecchia and Erkki Ruoslahti and Tambet Teesalu},
  journal={Chembiochem : a European journal of chemical biology},
  year={2016},
  volume={17 7},
  pages={
          570-5
        }
}
Cell surface p32, the target of LyP-1 homing peptide, is upregulated in tumors and atherosclerotic plaques and has been widely used as a receptor for systemic delivery of payloads. Here, we identified an improved LyP-1-mimicking peptide (TT1, CKRGARSTC). We used this peptide in a fluorescence polarization-based high-throughput screening of a 50,000-compound chemical library and identified a panel of compounds that bind p32 with low micromolar affinity. Among the hits identified in the screen… CONTINUE READING
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