New oxadiazole derivatives of isonicotinohydrazide in the search for antimicrobial agents: Synthesis and in vitro evaluation

Abstract

Structural modifications of the front line antitubercular drug isoniazid provide lipophilic adaptations of the drug in which the hydrazide moiety of isoniazid is replaced by 1,3,4-oxadiazole heterocycles to eliminate in vivo acetylation by arylamine N-acetyltransferase, which results in the formation of inactive acetylated drug. In the present study, a… (More)

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@inproceedings{Malhotra2012NewOD, title={New oxadiazole derivatives of isonicotinohydrazide in the search for antimicrobial agents: Synthesis and in vitro evaluation}, author={Manav Malhotra and Mohit Sanduja and Abdul Samad}, year={2012} }