New oral anticoagulants increase risk for gastrointestinal bleeding: a systematic review and meta-analysis.

@article{Holster2013NewOA,
  title={New oral anticoagulants increase risk for gastrointestinal bleeding: a systematic review and meta-analysis.},
  author={Ingrid Lisanne Holster and Vera E Valkhoff and Ernst J Kuipers and Eric T. T. L. Tjwa},
  journal={Gastroenterology},
  year={2013},
  volume={145 1},
  pages={
          105-112.e15
        }
}
BACKGROUND & AIMS A new generation of oral anticoagulants (nOAC), which includes thrombin and factor Xa inhibitors, has been shown to be effective, but little is known about whether these drugs increase patients' risk for gastrointestinal bleeding (GIB). Patients who require OAC therapy frequently have significant comorbidities and may also take aspirin and/or thienopyridines. We performed a systematic review and meta-analysis of the risk of GIB and clinically relevant bleeding in patients… CONTINUE READING

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and Drug Administration, US Department of Health and HumanServices

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