New opportunities in anti-hepatitis C virus drug discovery: targeting NS4B.

@article{Rai2011NewOI,
  title={New opportunities in anti-hepatitis C virus drug discovery: targeting NS4B.},
  author={Roopa Rai and Jerome Deval},
  journal={Antiviral research},
  year={2011},
  volume={90 2},
  pages={93-101}
}
Current therapy for chronic hepatitis C virus (HCV) infection constitutes a combination of pegylated interferon alfa-2a or alpha-2b and ribavirin. Although successful for many patient populations, this regimen has numerous limitations, including non-response, relapse, poor tolerability and long duration of treatment. To address these shortcomings, new small molecule agents are advancing in clinical development. Most of the current clinical candidates act by directly inhibiting key enzymes in… CONTINUE READING

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