New opportunities by synthetic biology for biopharmaceutical production in Pichia pastoris

  title={New opportunities by synthetic biology for biopharmaceutical production in Pichia pastoris},
  author={Thomas Vogl and Franz Stefan Hartner and Anton Glieder},
  booktitle={Current opinion in biotechnology},
Biopharmaceuticals are an integral part of modern medicine and pharmacy. Both, the development and the biotechnological production of biopharmaceuticals are highly cost-intensive and require suitable expression systems. In this review we discuss established and emerging tools for reengineering the methylotrophic yeast Pichia pastoris for biopharmaceutical production. Recent advancements of this industrial expression system through synthetic biology include synthetic promoters to avoid methanol… CONTINUE READING
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