New oncogenic subtypes in pediatric B-cell precursor acute lymphoblastic leukemia.

@article{Lilljebjrn2017NewOS,
  title={New oncogenic subtypes in pediatric B-cell precursor acute lymphoblastic leukemia.},
  author={Henrik Lilljebj{\"o}rn and Thoas Fioretos},
  journal={Blood},
  year={2017},
  volume={130 12},
  pages={1395-1401}
}
Until recently, 20% to 30% of pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) could not be classified into any of the established molecular subtypes. Recent molecular studies of such cases have, however, further clarified their mutational spectrum and identified new oncogenic subtypes consisting of cases with DUX4 rearrangements, ETV6-RUNX1-like gene expression, MEF2D rearrangements, and ZNF384 rearrangements. In this review, we describe these new subtypes, which account for… CONTINUE READING