New neolignans from the seeds of Myristica fragrans that inhibit nitric oxide production.

  title={New neolignans from the seeds of Myristica fragrans that inhibit nitric oxide production.},
  author={Gui-Yun Cao and Wen Xu and Xiu-wei Yang and Frank J. Gonzalez and Fei Li},
  journal={Food chemistry},
Five new 8-O-4' type neolignans, named myrifralignan A-E (1-5), together with five known analogues (6-10), were isolated from the seeds of Myristica fragrans Houtt. Their chemical structures were determined using several spectroscopic methods. Compounds 3-10 exhibited potent inhibitory activity against the production of nitric oxide (NO) in the RAW264.7 cell line stimulated by lipopolysaccaride. Myrislignan (7) and machilin D (10) were the most potent inhibitors of NO production amongst these… CONTINUE READING

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