New myeloablative conditioning regimen with fludarabine and busulfan for allogeneic stem cell transplantation: comparison with BuCy2

@article{Chae2007NewMC,
  title={New myeloablative conditioning regimen with fludarabine and busulfan for allogeneic stem cell transplantation: comparison with BuCy2},
  author={Yee Soo Chae and Sang Kyun Sohn and Jong Gwang Kim and Yoon Young Cho and Jong Ho Moon and Ho Jin Shin and Jae Seung Chung and Goon Jae Cho and Deok Hwan Yang and J J Lee and Y-K Kim and H S J Kim},
  journal={Bone Marrow Transplantation},
  year={2007},
  volume={40},
  pages={541-547}
}
A regimen of busulfan and cyclophosphamide (BuCy2) is regarded as the standard myeloablative regimen for SCT. This study evaluated the hypothesis that fludarabine can replace cyclophosphamide for myeloablative allogeneic SCT. Ninety-five patients underwent allogeneic SCT from HLA-identical donors, following BuCy2 (n=55) or busulfan+fludarabine (BF, n=40). The efficacy of fludarabine compared to cyclophosphamide was retrospectively evaluated. The BF group exhibited a shorter duration until… CONTINUE READING
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