New morpholine analogues of phencyclidine: Chemical synthesis and pain perception in rats

@article{Ahmadi2011NewMA,
  title={New morpholine analogues of phencyclidine: Chemical synthesis and pain perception in rats},
  author={Abbas Ahmadi and Mohsen Khalili and Ramin Hajikhani and Moslem Naserbakht},
  journal={Pharmacology Biochemistry and Behavior},
  year={2011},
  volume={98},
  pages={227-233}
}
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21 Citations

Synthesis and pain perception of new analogues of phencyclidine in NMRI male mice.
TLDR
It can be concluded that more analgesic effects of new BTCP analogues (VI and VII) may be concerned with antinociception activities of benzothiophene group and also with binding to cocaine site on the dopamine transporter receptor which seems to be more potent than PCP receptor in decreasing pain.
Synthesis and antinociceptive behaviors of new methyl and hydroxyl derivatives of phencyclidine.
TLDR
It was concluded that the new synthesized derivatives of PCP could substantially and respectively diminish acute and chronic pains.
New Amine and Aromatic Substituted Analogues of Phencyclidine: Synthesis and Determination of Acute and Chronic Pain Activities.
TLDR
It can be concluded that the benzylamine derivative of phencyclidine with a methyl group on benzyl position on phenyl ring (V) is more appropriate candidate to reduce acute and chronic pains compared to other substituted phenyl analogs (II-IV) and PCP.
Synthesis and study the analgesic effects of new analogues of ketamine on female wistar rats.
TLDR
The results indicated that in tail immersion and formalin tests, these new derivatives of ketamine were usually effective for decreasing pain on rats.
Synthesis and antinociception properties of phencyclidine derivatives with modified aromatic or cycloalkyl rings and amino group
TLDR
New phenyl and thienyl analogues with specific affinity for the phencyclidine sites in NMDA receptors, dopamine uptake blocking, or both of them were synthesized and showed better activities to decrease acute thermal and chemical, but not chronic pains.
Effect of phencyclidine derivatives on anxiety-like behavior using an elevated-plus maze test in mice.
TLDR
M and L compounds could be considered as a potential anxiolytic with less side effects due to a probable high electron donation of the methoxy group, as well as the hydrophilic properties of hydroxyl groups on these compounds.
Synthesis and Evaluation of Analgesic and Anti-Inflammatory Properties of Novel Ibuprofen Analogs
TLDR
Findings indicated that addition of substituted amino benzothiazoles to ibuprofen moiety as the main pharmacophore is a desirable strategy for reduction of pain and inflammation which may lead to the production of new drugs with higher activities compared to ib uprofen.
The antinociceptive effect of 4-substituted derivatives of 5-(4-chlorophenyl)-2-(morpholin-4-ylmethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione in mice
TLDR
It is demonstrated that combination of two different heterocyclic systems (morpholine and 1,2,4-triazole) might be beneficial for reduction of nociception.
Phencyclidine-Based New Psychoactive Substances.
TLDR
The aim of this chapter is to present a brief introductory overview of substances that have materialized as PCP-derived new psychoactive substances (NPS) in recent years and their known pharmacology.
Synthesis and theoretical activity evaluation of a new steroid-oxazolone derivative against COX 1-1 and COX-2
TLDR
The results showed that the steroid-oxazolone derivative has a higher affinity for COX 1 compared to indomethacin; however, it exhibits a lower affinity forCOX-2 in comparison with rofecoxib, suggesting that it could be a good candidate as COX-1 inhibitor translated as a possible drug for treatment of pain.
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