New monoclonal antibody (AIC) identifies interstitial cells of Cajal in the musculature of the mouse gastrointestinal tract

@article{Torihashi2004NewMA,
  title={New monoclonal antibody (AIC) identifies interstitial cells of Cajal in the musculature of the mouse gastrointestinal tract},
  author={Shigeko Torihashi and Kakeru Yokoi and Hisao Nagaya and Katsunori Aoki and Toyoshi Fujimoto},
  journal={Autonomic Neuroscience},
  year={2004},
  volume={113},
  pages={16-23}
}
Interstitial cells of Cajal (ICC) are pacemaker cells for the spontaneous muscular contractions and neuromodulators that mediate neurotransmission from enteric neurons to smooth muscle cells in the gastrointestinal (GI) tract. They express c-Kit, and the antibody for c-Kit (especially ACK2) has been a useful tool for functional and morphological studies. ACK2, however, does not work on tissues fixed with paraformaldehyde, and not all ICC express c-Kit in human. Therefore, in order to find a new… CONTINUE READING
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